The last proposed system of RBC vasodilation within the presence of nitrite is the reduction of nitrite to NO by Hb. Brooks initially examined the nitrite Hb conversation in 1937 and this get the job done was afterwards prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks, 1